Ingredient guide
What is PDRN in skincare?
A plain-language guide to salmon-derived PDRN, why concentration matters and what to check before choosing a PDRN serum.
Written by UNA
What PDRN means in skincare
PDRN stands for polydeoxyribonucleotide. In cosmetic formulas, it refers to purified DNA fragments used as one component within a wider skincare formula. The full formula matters: concentration, supporting ingredients, texture, packaging and how consistently the product fits your routine all influence the experience.
Salmon-derived PDRN in Signal Serum
Signal Serum uses salmon-derived Sodium DNA (PDRN). It contains 200,000 ppm, equal to 20%, in the finished formula. We disclose the source and concentration so customers can make an informed choice.
Cosmetic PDRN should not be confused with an in-clinic procedure. A topical serum is a cosmetic product and should be evaluated by its ingredient list, directions and documented cosmetic claims.
What to look for in a PDRN serum
Look beyond the front label. Check the PDRN concentration, source, supporting ingredients and complete ingredient list. Signal Serum pairs PDRN with 2% niacinamide, hydration-supporting ingredients and targeted peptides.
If your skin is sensitive-feeling, patch test first and introduce one new product at a time.
A simpler treatment step
Signal Serum
Signal Serum contains 200,000 ppm salmon-derived PDRN, 2% niacinamide, peptides and a multi-hydration complex in one lightweight daily treatment step.
$39.99
Explore Signal Serum
Questions, answered
What readers often ask.
Is the PDRN in Signal Serum salmon-derived?
Yes. Signal Serum contains salmon-derived Sodium DNA (PDRN).
Can PDRN replace moisturizer?
A serum and moisturizer play different roles. Apply a serum as directed, then use a moisturizer if your skin needs it.